An AFM facility

  Physical Biochemistry - Research
People and Aims | Methodologies | Research | Publications | Opportunities |
Science communication | Dengue – our work | Pain - our work | In the press |

On-going projects

 

 

  • 2009/2013 - LIPIDENGUE: The role of hepatic lipid membranes and lipid droplets in Dengue virus encapsidation. A gateway to new therapies. (PTDC/QUI-BIQ/112929/2009)
  • Structural characterization at the molecular level of vector peptides to transfect macromolecules across lipidic membranes. Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bacteria, dengue virus and neurodegeneration (MEMPEPACROSS). Marie Curie International Research Staff Exchange Scheme (IRSES, FP7-PEOPLE-2009-IRSES), Collaboration with Biomembraes Unit
  • Study of the inhibitory action of peptides on the fusion of the virus HIV-1 at the molecular level (PTDC/QUI-BIQ/104787/2008, collaboration with Biomembranes Unit).
  • Peptides as drug candidates directed to pain and neurodegeneration (Pep2Brain), EC-FP7 Marie Curie Industry-Academia Partnerships and Pathways (IAPP), Grant nº 230654
  • Toward the development of peptide-based hydrogels for tissue regeneration applications with inherent antibacterial activity. (EC, FP7-PEOPLE-IOF-2008-235154) (FCT, PTDC/SAU-BEB/099142/2008)

(all on-going projects involve collaborations)


Completed projects
  • Structural characterization of a drug carrier system by Rayleigh light scattering
  • A model for the action of anti-fugi polyenes at the molecular level
  • The interaction of kyotorphin with lipidic membranes. Maximizing permeability conditions. (PTDC/SAU-FCT/69493/2006)
  • The interaction of Dengue virus proteins with lipids. (PTDC/SAU-FCT/69937/2006)
  • The molecular mode of action of antimicrobial peptides and other membrane-active peptides (CRUP-DAAD, Portuguese-German Joint Project A-6/08).
  • Elucidating the mechanism of action of cyclotides; ultra-stable proteins from plants. European Comission. PIOF-GA-2008-220318 (joint project with the Institute for Molecular Biosciences, The University of Queensland, Australia) 

Main collaborations





 

 

 

Tecnology Transfer

Fusogen (China)
Instituto de Biología Molecular y Celular (UMH, Elche, Espanha) / Prof. José Villalaín
Instituto de Bioquímica Médica (UFRJ, Brasil) / Prof. Dr.a Andrea Da Poian
Instituto de Histologia e Embriologia (Univ. Porto) / Prof. Isaura Tavares
Instituto Superior Técnico (UTL) / Prof. Dr. Manuel Prieto
LIPPSO (Univ. Girona, Spain) / Prof. Eduard Bardají
Roche (USA)
University Karlsruhe (Germany) / Prof. Anne Ulrich
Universidade de Queensland (Australia) / Prof David Craik
Xoma (USA)


Bioalvo (Portugal)

Synovo, FP7 Project Framework (Germany)

Technoantibodies, FP7/QREN DoIT Project (Portugal)

FP7 Project - Pep2Brain

 

Scientific Interactive Multimedia - TakeTheWind (BEOn, Consultants) 

 



 

Av. Professor Egas Moniz
Edifício Egas Moniz,
1649-028 Lisboa
Portugal
 

Tel: (+351)217985136
Fax: (+351)217999477


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