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MCastanho

Editor 

 Journal of peptide Science 2008, 14(4). Guest editors: M. Castanho, M. Dathe. Special issue: Biophysics of membrane-active peptides 

Current research insights intoHIV/AIDS and related diseases (N. Taveira, M. Castanho, H. Barroso Eds), SIDAnet, Lisbon, 2008. (ISBN 978-972-95977-7-0; Bilingual Portuguese/English; 8th virtual congress HIV-AIDS)

 

Membrane-Active Peptides: Methods and Results on Structure ad Functions (Castanho, M Ed.), IUL-pressPublishers (La Jolla, CA, USA)

The Researching, Teaching and Learning Triangle, (Castanho, M and Güner-Akdogan, G. Ed.); Springer (New York, NY, USA) ISBN 13: 9781461405672, ISBN 10: 146140567X; (28 November 2011)

Peptide Drug Discovery and Development - Translational Research in Academia and Industry, 1st Edition,(Castanho, M. and Santos, N. Ed.); Wiley-VCH, (Weinheim, Germany), ISBN-10: 3-527-32891-2, ISBN-13: 978-3-527-32891-8, (October 2011) (See ChemMedChem Critics

Book Chapters 

Kaas Q, Westermann JC, Henriques ST and Craik DJ (2010) Antimicrobial Peptides in Plants. In “Antimicrobial peptides, Discovery, Design and Novel Therapeutic Strategies” (Wang G, Ed.) CABI (Oxfordshire, UK), pp 40-70. ISBN: 978-1-84593-657-0.


Henriques ST (2010) Biophysics and the way out of the endosomal versus non-endosomal dilemma for cell-penetrating peptides pep-1. In "Membrane Active Peptides: Methods and Results on Structure and Function" (Castanho M, Ed.) IUL Publishers (La Jolla, CA, USA), pp 377-414. ISBN: 978-0-9720774-5-3.


Veiga AS, Franquelim HG, HIV-1 Fusion Inhibitor Peptides: A Cross Correlation between Efficacy and Membrane-Level Activity, In "Membrane Active Peptides: Methods and Results on Structure and Function" (Castanho M, Ed.) IUL Publishers (La Jolla, CA, USA), pp 495-528. ISBN: 978-0-9720774-5-3.


Journal Cover

 Biopolymers 100, 325-336. (2013)

Peptides as models for the structure and function of viral capsid proteins: insight on dengue virus capsid. Freire J.M., Veiga A.S., de la Torre B.G., Santos N.C., Andreu D., Da Poian A.T., Castanho M.A.R.B.

Biopolymers_2013_Freire

 


 

Short List of Selected Publications


Intracellular nucleic acid delivery by the supercharged Dengue vírus capsid protein. Freire JM, Veiga AS, Conceição TM, Kowalczky W, Mohana-Borges R, Andreu D, Santos NC, Da Poian AT, Castanho MARB.(2013)  PloS One 12(8), doi: 10.1371/journal.pone.0081450.
Arginine-rich self-assembling peptides as potent antibacterial gels. Veiga AS, Sinthuvanich C, Gaspar D, Franquelim HG, Castanho MA, Schneider JP. Biomaterials. 2012 Sep 17. pii: S0142-9612(12)00949-0.doi: 10.1016/j.biomaterials.2012.08.046. PMID: 22995710
Anticancer Peptide SVS-1: Efficacy Precedes Membrane Neutralization. Gaspar D, Veiga AS, Sinthuvanich C,Schneider JP, Castanho MA. Biochemistry. 2012 Aug 14;51(32):6263-5. Epub 2012 Aug 3. PMID: 22839778
From antimicrobial to anticancer peptides. A review. Gaspar D, Veiga AS, Castanho MARB. (2013) Front Microbiol. 4, 294, 1-16. http://dx.doi.org/10.3389/fmicb.2013.00294.

The Mechanism of Action of Antimicrobial Peptides: Lipid Vesicles vs. Bacteria. Melo MN, Castanho MA. Front Immunol. 2012;3:236. Epub 2012 Aug 2. PMID: 22876247

Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia. Ribeiro MM, Pinto AR, Domingues MM, Serrano I, Heras M, Bardaji ER, Tavares I, Castanho MA. Mol Pharm. 2011 Oct 3;8(5):1929-40. Epub 2011 Aug 24. PMID: 21830793
Decoding the Membrane Activity of the Cyclotide Kalata B1. The Importance of Phosphatidiletanolamine Phospholipids and Lipid Organization on Hemolytic and anti-HIV Activities. Henriques, ST, Huang, YH, Rosengren, KJ, Franquelim, HG, Carvalho, FA, Johnson, A, Sonza, S, Tachedjian, G, Castanho, MARB, Daly, NL, Craik, DJ. Journal of Biological Chemistry. 286:27, 24231-24241, DOI: 10.1074/jbc.M111.253393
Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes. Franquelim, HG,Chiantia, S, Veiga, AS, Santos, NC, Schwille, P, Castanho, MARB. AIDS, 25:4, 419-428. DOI:10.1097/QAD.0b013e328342ff11 (2011)
Escherichia coli Cell Surface Perturbation and Disruption Induced by Antimicrobial peptides BP100 andpepR. Carla S Alves, Manuel N Melo, Henri G Franquelim, Rafael Ferre, Marta Planas, Lidia Feliu,Eduard Bardají, Wioleta Kowalczyk, David Andreu, Nuno C Santos, Miguel X Fernandes, Miguel A R BCastanho.  J Biol Chem (2010) vol. 285 (36) pp. 27536-44
Antimicrobial peptides: linking partition, activity and high membrane.bound concentrations. M. N. Melo, R.Ferre and M. Castanho (2009) Nature Rev Microbiology
How to address CPP and AMP translocation? Methods to detect and quantify peptide internalization in vitro and invivo. S. T. Henriques, M. N. Melo, M. A. R. B. Castanho (2007) Molec Membrane Biol 24, 173-184.

Cell-penetrating peptides and antimicrobial peptides: how different are they? S. T. Henriques, M. N. Melo, M A. R. B.Castanho (2006) Biochem J. 399, 1–7 

Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods. NC Santos, M Prieto, MARB Castanho (2003) Biochem Biophys Acta, 1612, 123-135.

 

2014

"The Mechanisms and Quantification of the Selective Permeability in Transport Across Biological Barriers: The Example of Kyotorphin." Isa D Serrano, João M Freire, Manuel N Melo, Miguel V Carvalho, Mafalda Neves, and Miguel A R B Castanho. Mini Rev Med Chem (2014).PubMed
"Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action." (2014) Freire JM, Veiga AS, Rego de Figueiredo I, de la Torre BG, Santos NC, Andreu D, Da Poian AT, Castanho MA. FEBS J. 281, 191–215.PubMed


2013

"Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria." Torcato I. M., Huang Y. H., Franquelim H. G., Gaspar D., Craik D. J., Castanho M. A.R.B., Troeira S. T. (2013)  Biochimica et Biophysica Acta 1828, 944-955. http://dx.doi.org/10.1016/j.bbamem.2012.12.002PubMed
"Quantifying molecular partition of cell-penetrating peptides-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems." Freire J.M., Veiga A.S., de la Torre B.G., Andreu D., Castanho M.A.R.B. (2013) J. Pep. Sci. 19, 182-189.PubMed
"Side-effects of analgesic kyotorphin derivatives:advantages over clinical opioid drugs." Ribeiro MM, Santos SS, Sousa DS, Oliveira M, Santos SM, Heras M, Bardaji E, Tavares I, Castanho MA (2013) Amino Acids. 45(1), 171-178, doi: 10.1007/s00726-013-1484-2.PubMed
"Decoding distinct membrane interactions of HIV-1 fusion inhibitors using a combined atomic force and fluorescence microscopy approach." Franquelim H. G., Gaspar D., Veiga, A. S., Santos, N. C., Castanho, M. A.R.B. (2013)  Biochimica Biophysica Acta 1828, 1777-1785. http://dx.doi.org/10.1016/j.bbamem.2013.03.006PubMed
"Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increase peptide membrane interactions potentiating its action" Hollmann A, Matos PM, Augusto MT, Castanho MARB and Santos NC. (2013) PLoS ONE, 8(4): e60302. doi: 10.1371/journal.pone.0060302PubMed
"A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion" Vigant F, Lee J, Hollmann A, Tanner LB, Akyol Ataman Z, Yun T, Shui G, Aguilar HC, Zhang D, Meriwether D, Roman-Sosa G, Robinson LR, Juelich TL, Buczkowski H, Chou S, Castanho MA, Wolf MC, Smith JK, Banyard A, Kielian M, Reddy S, Wenk MR, Selke M, Santos NC, Freiberg AN, Jung ME, Lee B. (2013) PLoS Pathog, 9(4), doi: 10.1371/journal.ppat.1003297.PubMed
"N-terminal AH2 segment of protein NS4B from hepatitis C virus. Binding to and interaction with biomembranes." Palomares-Jerez MF, Nemesio H., Franquelim HG, Castanho MA, Villalaín J. (2013) Biochim Biophys Acta, 1828(8), 1938-1952. doi: 10.1016/j.bbamem.2013.04.020PubMed
"rBPI21 interact with negative membranes endothermically promoting for formation of rigid" Domingos MM., Bianconi ML., Barbosa LR., Santiago PS, Tabak M, Castanho MA, Itri R, Santos NC, (2013) Biochim Biophys Acta, 1828(11),2419-2427. doi:10.1016/j.bbamem.2013.06.009PubMed
"Dengue virus capsid protein interacts specifically with very low-density lipoproteins." Faustino AF, Carvalho FA, Martins IC, Castanho MA, Mohana-Borges R, Almeida FC, Da Poian AT, Santos NC, (2013) Nanomedicine, 10(1), 247-255, doi: 10.1016/j.nano.2013.06.004PubMed
"Peptides as models for the structure and function of viral capsid proteins: insight on dengue virus capsid." Freire J.M., Veiga A.S., de la Torre B.G., Santos N.C., Andreu D., Da Poian A.T., Castanho M.A.R.B. (2013)  Biopolymers 100, 325-336. (Journal Cover)PubMed
"The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability." Torcato IM., Huang YH, Franquelim HG, Gaspar D, Craik DJ, Castanho MARB, Henriques ST, (2013) ChemBioChem, 14, 2013-2022.  http://dx.doi.org/10.1002/cbic.201300274.PubMed
"From antimicrobial to anticancer peptides. A review." Gaspar D, Veiga AS, Castanho MARB. (2013) Front. Microbiol. 4, 294, 1-16. http://dx.doi.org/10.3389/fmicb.2013.00294.PubMed
"Antimicrobial protein rBPI21-induced surface changes on Gram-negative and Gram-positive bacteria." Domingos MM, Silva PM, Franquelim HG, Carvalho FA, Castanho MA, Santos NC. (2013)  Nanomedicine. doi:10.1016/j.nano.2013.11.002 (Journal IF:6.930; Times cited:0) PubMed
"Antimicrobial hydrogels for the treatment of infection." Veiga A.S., Schneider J.P. (2013) Biopolymers 100, 637-644. (Journal IF: 2.879; Times cited: 0)PubMed
"Intracellular nucleic acid delivery by the supercharged Dengue vírus capsid protein." Freire JM, Veiga AS, Conceição TM, Kowalczky W, Mohana-Borges R, Andreu D, Santos NC, Da Poian AT, Castanho MARB. (2013)  Plos one 12(8), doi: 10.1371/journal.pone.0081450. (Journal IF: 3.730; Times cited: 0)PubMed
"The Use of Visual Analog Scales to Compare Pain Between Patients With Alzheimer Disease and Patients Without Any Known Neurodegenerative Disease and Their Caregivers." Santos S., Castanho M. (2013) Am. J. Alzheimers Dis Other Demen, 28(8), doi: 10.1177/1533317513517046PubMed
"Neuropeptide kyotorphin (tyrosyl-arginine) has decreased levels in the cerebro-spinal fluid of Alzheimer’s disease patients: potential diagnostic and pharmacological implications." Santos MS, Garcia-Nimo L, Sá Santos S, Tavares I, Cocho JA, Castanho MA. (2013)  Frontiers in Ageing Neurosciences 68 (5), 1-6.  doi: 10.3389/fnagi.2013.00068.PubMed
"Arginine-rich self-assembling peptides as potent antibacterial gels." Veiga AS, Sinthuvanich C, Gaspar D, Franquelim HG, Castanho MA, Schneider JP. Biomaterials. 2012 Sep 17. pii: S0142-9612(12)00949-0. doi: 10.1016/j.biomaterials.2012.08.046. PMID: 22995710PubMed


2012 

"Anticancer β-hairpin peptides: membrane-induced folding triggers activity." Sinthuvanich C, Veiga AS, Gupta K, Gaspar D, Blumenthal R, Schneider JP. (2012) JACS.134(14):6210-7. DOI: 10.1021/ja210569f. 14,6210.PubMed
"Arginine-rich self-assembling peptides as potent antibacterial gels." Veiga AS, Sinthuvanich C, Gaspar D, Franquelim HG, Castanho MA, Schneider JP. Biomaterials. 2012 Sep 17. pii: S0142-9612(12)00949-0. doi: 10.1016/j.biomaterials.2012.08.046. PMID: 22995710PubMed
"Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation."Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF. J Neurosci. 2012 Aug 22;32(34):11750-11762. PMID: 22915117PubMed
"Phosphatidylethanolamine-binding is a conserved feature of cyclotide-membrane interactions." Henriques ST, Huang YH, Castanho MA, Bagatolli LA, Sonza S, Tachedjian G, Daly NL, Craik DJ. J Biol Chem. 2012 Aug 17. [Epub ahead of print] PMID: 22854971PubMed
"Anticancer Peptide SVS-1: Efficacy Precedes Membrane Neutralization." Gaspar D, Veiga AS, Sinthuvanich C, Schneider JP, Castanho MA. Biochemistry. 2012 Aug 14;51(32):6263-5. Epub 2012 Aug 3. PMID: 22839778PubMed
"The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif." Martins IC, Gomes-Neto F, Faustino AF, Carvalho FA, Carneiro FA, Bozza PT, Mohana-Borges R, Castanho MA, Almeida FC, Santos NC, Da Poian AT. Biochem J. 2012 Jun 15;444(3):405-15. PMID: 22428600PubMed
"Antimicrobial properties of analgesic kyotorphin peptides unraveled through atomic force microscopy." Ribeiro MM, Franquelim HG, Torcato IM, Ramu VG, Heras M, Bardaji ER, Castanho MA. Biochem Biophys Res Commun. 2012 Apr 13;420(3):676-9. Epub 2012 Mar 17. PMID: 22450328PubMed
"Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins." Carvalho FA, Carneiro FA, Martins IC, Assunção-Miranda I, Faustino AF, Pereira RM, Bozza PT, Castanho MA, Mohana-Borges R, Da Poian AT, Santos NC. J Virol. 2012 Feb;86(4):2096-108. Epub 2011 Nov 30. PMID: 22130547PubMed

"The Mechanism of Action of Antimicrobial Peptides: Lipid Vesicles vs. Bacteria." Melo MN, Castanho MA. Front Immunol. 2012;3:236. Epub 2012 Aug 2. PMID: 22876247

PubMed

 



2011

"Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia." Ribeiro MM, Pinto AR, Domingues MM, Serrano I, Heras M, Bardaji ER, Tavares I, Castanho MA. Mol Pharm. 2011 Oct 3;8(5):1929-40. Epub 2011 Aug 24. PMID: 21830793PubMed
"Decoding the Membrane Activity of the Cyclotide Kalata B1. The Importance of Phosphatidiletanolamine Phospholipids and Lipid Organization on Hemolytic and anti-HIV Activities." Henriques, ST, Huang, YH, Rosengren, KJ, Franquelim, HG, Carvalho, FA, Johnson, A, Sonza, S, Tachedjian, G, Castanho, MARB, Daly, NL, Craik, DJ. Journal of Biological Chemistry. 286:27, 24231-24241, DOI: 10.1074/jbc.M111.253393  (JUL 8 2011)PubMed
"Inhibition of nociceptive responses after systemic administration of amidated kyotorphin" Ribeiro, MMB, Pinto, A, Pinto, M, Heras, M, Martins, I, Correia, A, Bardaji, E, Tavares, I, Castanho, M. British Journal of Pharmacology, 163:5, 964-973 DOI: 10.1111/j 1476-5381.2011.01290.x (JUL 2011)Wiley
"Using Zeta-potential Measurements to Quantify Peptide Partition to Lipid Membranes"Freire, JM, Domingues, MM, Matos, J, Melo, MN, Veiga, AS, Santos, NC, Castanho, MARB, Eur Biophys J 40:4, SI:481-487, DOI: 10.1007/s00249-010-0661-4 (APR 2011)PubMed
"Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes" Franquelim, HG, Chiantia, S, Veiga, AS, Santos, NC, Schwille, P, Castanho, MARB. AIDS, 25:4, 419-428. DOI: 10.1097/QAD.0b013e328342ff11 (FEB 20 2011)
PubMed


2010

"The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide." Matos PM, Freitas T, Castanho MA, Santos NC. Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):270-4. Epub 2010 Nov 12.PubMed
"In vitro blood-brain barrier models--latest advances and therapeutic applications in a chronological perspective." Ribeiro MM, Castanho MA, Serrano I. Mini Rev Med Chem. 2010 Mar;10(3):262-70.PubMed
"HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes." Matos PM, Castanho MA, Santos NC. PLoS One. 2010 Mar 23;5(3):e9830.PubMed
"Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes." Franquelim HG, Veiga AS, Weissmüller G, Santos NC, Castanho MA. Biochim Biophys Acta. 2010 Jun;1798(6):1234-43. Epub 2010 Feb 11.PubMed
"Fast Membrane Assiciation is Crucial factor in the peptide pep-1 Translocation mechanism: a kinetic study by surface plasmon resonance" Henriques ST, Castanho MA, Pattenden LK, Aquilar MI. Biopolymers. 2010; 94 (3): 314-22

PubMed

"Is PrP (106-126) fragment involved in the membrane activity of the Prion protein?". Henriques ST, Castanho MA. Curr Protein Pept Sci. 2010 Aug; 11(5) 326-33

PubMed

"Drug-lipid interaction evaluation: why a 19th century solution?". Ribeiro MMB, Melo MN, Serrano ID, Santos NC and Castanho MARB (2010) Trends in Pharmacological Sciences (2010) vol. 31 pp. 449-454

PubMed

"Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies." Pedro M Matos, Henri G Franquelim, Miguel A R B Castanho, Nuno C Santos. Biochim Biophys Acta (2010) vol. 1798 (11) pp. 1999-2012

PubMed

"Escherichia coli Cell Surface Perturbation and Disruption Induced by Antimicrobial peptides BP100 and pepR". Carla S Alves, Manuel N Melo, Henri G Franquelim, Rafael Ferre, Marta Planas, Lidia Feliu, Eduard Bardají, Wioleta Kowalczyk, David Andreu, Nuno C Santos, Miguel X Fernandes, Miguel A R B Castanho.  J Biol Chem (2010) vol. 285 (36) pp. 27536-44

PubMed

"Cyclotides as templates in drug design."Henriques ST and Craik DJ (2010)  Drug Discov Today 15, 57-64. PubMed


2009

"rBPI21 Promotes Lipopolysaccharide Aggregation and exerts Its Antimicrobial Effects by (Hemi)fusion of PG.Containing membranes.", M. M. Domingues, M. A. R. B. Castanho and N. C. Santos (2009) PLoS ONE, 4PubMed
“Interaction of the dengue virus fusion peptide with membranes assessed by NMR: The essential role of the envelope protein TRP101 for membrane fusion.”, Melo MN, Sousa FJ, Carneiro FA, Castanho MA, Valente AP, Almeida FC, Da Poian AT, Mohana-Borges R. (2009) J Mol Biol.PubMed
“Interactions of HIV-1 antibodies 2F5 and 4E10 with a gp41 epitope prebound to host and viral membrane model systems” Ana S. Veiga, Leonard K. Pattenden, Jordan M. Fletcher, Miguel A. R. B. Castanho and Marie Isabel Aguilar (2009) ChemBioChem, 10, 1032–1044 PubMed
"The Toxicity of Prion Protein Fragment PrP (106-126) is Not Mediated by Membrane Permeabilization as Shown by M112W substituition"; S. T. Henriques, L. K. Pattenden, M. I. Aguilar and M. A. R. B. Castanho (2009) Biochemistry, 48, 4198-4208

PubMed

Free PDF 

"Antimicrobial peptides: linking partition, activity and high membrane.bound concentrations"; M. N. Melo, R. ferre and M. Castanho (2009) Nature Rev. MicrobiologyPubMed
"Synergistic effects of the membrane actions of cecropin-melitin antimicrobial hybrid peptide BP100"; R. Ferre, M. N. Melo, A. D. Correia, L. Feliu, E. Bardají, M. Planas and M. castanho (2009) Biophys. J.PubMed
"Fold-Unfold transitions in the selectivity and mechanism of action of the N-terminal fragment of the Bactericidal/Permeability-Increasing protein (rBPI21)"; M. M. Domingues, S. C. D. N. Lopes, N. C. Santos, A. Quintas and M. A. R. B. Castanho (2009), Biophys. J.PubMed


2008

 "PrP(106-126) does not interact with membranes under physiological conditions." Henriques ST, Pattenden LK, Aguilar MI, Castanho MA. Biophys J. 2008 Aug;95(4):1877-89. Epub 2008 May 9

PubMed

 "Sifuvirtide screens rigid membrane surfaces. establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides."Franquelim HG, Loura LM, Santos NC, Castanho MA. J Am Chem Soc. 2008 May 14;130(19):6215-23. Epub 2008 Apr 15

PubMed
PubMed
“What can light scattering spectroscopy do for membrane-active peptide studies?”; M. M. Domingues, P. S. Santiago, M.A.R.B. Castanho, N. C. Santos (2008) J. Pept. Sci., 14, 394-400. PubMed
“Enfuvirtide effects on human erythrocytes and lymphocytes functional properties.”; C. R. Vieira, M. Castanho, C. Saldanha, N. C. Santos (2008) J. Pept. Sci., 14, 448-454 PubMed
"Translocation or membrane disintegration? Implication of peptide-membrane interactions in pep-1 activity." S.T. Henriques, M. Castanho (2008) J. Pept. Sci., 482-487 PubMed
2007
“Molecular interaction studies of peptides using steady-state fluorescence intensity. Static (de)quenching revisited.”; M. M. Ribeiro, H. Franquelim, M. Castanho, A. S. Veiga (2007) J. Pept. Sci., 14, 401-406PubMed
"Hepatitis C virus core protein binding to lipid membranes. The role of domains 1 and 2." Ana J. Pérez-Berná, Ana Salomé Veiga, Miguel A.R.B. Castanho, and José Villalaín (2007) J. Viral Hepatitis, 15, 346-356PubMed
"The influence of cholesterol on the interaction of HIV gp41 membrane proximal region-derived peptides with lipid bilayers"; A.S. Veiga, M. Castanho (2007) FEBS J, 274,5096-5104PubMed
"How to address CPP and AMP translocation? Methods to detect and quantify peptide internalization in vitro and in vivo"; S. T. Henriques, M. N. Melo, M. A. R. B. Castanho (2007) Molec. Membrane Biol 24, 173-184.PubMed
Energy-independent translocation of cell-penetrating peptides occurs without formation of pores. A biophysical study with pep-1."; S.T. Henriques, A. Quintas, L. A. Bagatolli, F. Homblé, M.A.R.B. Castanho (2007) Molec. Membrane Biol 24, 282-293.PubMed
"Omiganan interaction with bacterial membranes and cell wall models. Assigning a biological role to saturation."; M. N. Melo, M.A.R.B. Castanho (2007) Biochimica et Biophysica Acta 1768, 1277–1290PubMed


2006
"Cell-penetrating peptides and antimicrobial peptides: how different are they?";S. T. Henriques, M. N. Melo, M A. R. B. Castanho (2006) Biochem. J. 399, 1–7

PubMed

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“Chiral Recognition of D-Kyotorphin by Lipidic Membranes: Relevance Toward Improved Analgesic Efficiency”; S. C. D. N. Lopes, A. Fedorov, M. A. R. B. Castanho (2006) ChemMedChem 1, 723-728.

PubMed

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“The membranes’ role in the HIV-1 neutralizing monoclonal antibody 2F5 mode of action needs re-evaluation”; A. S. Veiga, M. A.R.B. Castanho (2006) Antiviral Res. 71, 69-72.

PubMed

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“Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides”; M. N. Melo, D. Dugourd, M. A. R. B. Castanho (2006) Recent Patent Rev. Anti-infective Drug Discovery 1, 201-207.

PubMed

"Conformational and Orientational Guidance of the Analgesic Dipeptide Kyotorphin Induced by Lipidic Membranes: Putative Correlation toward Receptor Docking”;S. C. D. N. Lopes, C. M. Soares, A. M. Baptista, E. Goormaghtigh, B. J. Costa Cabral, M. A. R. B. Castanho (2006) J. Phys. Chem. B 110, 3385-3394.

PubMed

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"Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions" S. Veiga, Y. Yuan, X. Li, N. Santos, G. Liu, M. Castanho (2006) BBA - Gen Subjects, 1760, 55 - 61PDF


2005

"Re-evaluating the role of strongly charged sequences in amphipathic cell-penetrating peptides.A fluorescence study using Pep-1.";  S. T. Henriques, J. Costa; M. A. R. B. Castanho (2005) FEBS Lett.,4498-4502.PDF available
"Overview of Common Spectroscopic Methods to Determine the Orientation/Alignment of Membrane Probes and Drugs in Lipidic Bilayers"; S. Lopes, M. A. R. B. Castanho (2005) Curr. Org.Chemistry, 9; 889-898.PDF available
"Translocation of b-Galactosidase M
 

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