-
Selected
Publications
J.
Galindo-Villegas, D. García-Moreno, S. de Oliveira, J. Meseguer, V.
Mulero, (2012) Regulation of immunity and
disease resistance by commensal microbes and chromatin modifications
during zebrafish development.” Proc Natl Acad Sci U S A., Sep 25,
109(39), 2605-2614
de
Almeida VV, Calado A, Rosário HS, Saldanha C. (2012) Differential
effect of soluble fibrinogen as a neutrophil activator. Microvasc
Res. 83(3):332-6.
C.
Saldanha, (2012) Fibrinogen interaction
with the red blood cell membrane. Clin Hemorheol Microcirc., Sep 7.
[Epub ahead of print]
C.
Saldanha, T. Freitas, JP. Almeida, (2012)
Fibrinogen effects on erythrocyte nitric oxide mobilization in
presence of acetylcholine. Life Sci., Jul 11. [Epub ahead of print]
P.
de Oliveira, AQ Gomes, TR Pacheco, V Vitorino de Almeida, C Saldanha,
A Calado, (2012) Cell-specific regulation
of acetylcholinesterase expression under inflammatory conditions.
Clin Hemorheol Microcirc. 51(2), 129-37.
JP
Lopes de Almeida, T Freitas-Santos, C Saldanha, (2012) Erythrocyte
deformability dependence on band 3 protein in an in-vitro model of
hyperfibrinogenemia. Clin Hemorheol Microcirc, 50(3), 213-9.
Lopes
de Almeida, JP, Freitas-Santos, T, Saldanha, C. (2011)
Evidence that the degree of band 3 phosphorylation modulates human
erythrocytes nitric oxide efflux - in vitro model of
hyperfibrinogenemia. Clinical
Hemorheology and Microcirculation 49 (1), 407-16.
Saldanha,
C, Lopes de Almeida, JP. (2011) Erythrocyte
as a link between basic and clinical research. Clinical
Hemorheology and Microcirculation 49 (1), 463-72.
Moura,
RA, Cascao, R, Perpetuo, I, Canhao, H, Vieira-Sousa, E, Mourao, AF,
Rodrigues, AM, Polido-Pereira, J, Queiroz, MV, Rosario, HS,
Souto-Carneiro, MM, Graca, L, Fonseca, JE. (2011)
Cytokine pattern in very early rheumatoid arthritis favours B-cell
activation and survival. Rheumatology
50 (2), 278-282
de
Oliveira, S, de Almeida, VV, Calado, A, Rosário, HS, Saldanha, C.
(2011) Integrin-associated protein (CD47) is a putative mediator for
soluble fibrinogen interaction with human red blood cells membrane.
Integrin Biochim Biophys Acta
1818 (3), 481-490
Santos,
MJ, Pedro, LM, Canhão, H, Fernandes e Fernandes, J, Canas da Silva,
J, Fonseca, JE, Saldanha C. (2011) Hemorheological parameters are
related to subclinical atherosclerosis in systemic lupus
erythematosus and rheumatoid arthritis patients. Atherosclerosis
219(2), 821-6.
Silva-Herdade,
AS, Saldanha, C. (2011) Hemorheological effects of valsartan in
L-NAME induced hypertension in rats. The
Open Circ Vasc J 4, 1-5.
Lopes
de Almeida JP, Freitas-Santos, T, Saldanha C. (2011) Erythrocyte
deformability dependence on Band 3 protein in an in vitro model of
hyperfibrinogenemia. Clin Hemorh Microc 44, 1-6.
Lopes
de Almeida, JP, de Oliveira, S, Saldanha, C. (2011) Erythrocyte as a
Biological Sensor. Clin Hemorh Microc 48, 1-20.
Saldanha,
C, Lopes de Almeida, JP, Freitas, T, Oliveira, S, Silva-Herdade, AS.
(2010) Erythrocyte deformability responses to
shear stress under external and internal stimuli influences. Series
on Biomechanics 25, 54-60.
Lopes
de Almeida J.P., Saldanha, C. (2010) Dithiothreitol
revisited in red cells: a new head for an old hat. Clin
Hemorheol Microcirc.
46,
51-56.
Martin
Martins, J., Vale, S., Ferreira, F., Fagundes, M.J., Carmo, I.,
Saldanha, C., Martins e Silva, J. (2010) Plasma
corticotropin releasing hormone during the feeling of induced
emotions. Neuro
Endocrinol Lett.
31, 250-5.
de
Almeida, J.P., Saldanha, C. (2010) Nonneuronal
cholinergic system in human erythrocytes: biological role and
clinical relevance. J
Membr Biol.
234(3), 227-34.
Santos,
N.C., Silva, J.M., Freitas, T., Doroana, M., Duarte, N., Tavares, L.,
Antunes, F., Saldanha, C. (2010) Blood
cell membrane fluidity and intracellular Ca2+
changes in antiretroviral-naïve and -treated HIV-1-infected
patients.
The
Scientific World Journal.
10, 350-5.
de
Oliveira, S., Saldanha, C. (2010) An
overview about erythrocyte membrane. Clin
Hemorheol Microcirc.
44, 63-74.
Cascão
R, Moura RA, Perpétuo I, Canhão H, Vieira-Sousa E, Mourão AF,
Rodrigues AM, Polido-Pereira J, Queiroz MV, Rosário HS,
Souto-Carneiro MM, Graca L, Fonseca JE (2010) Identification
of a cytokine network sustaining neutrophil and Th17 activation in
untreated early rheumatoid arthritis. Arthritis
Res Ther 12, R196.
Cascão
R, Rosário HS, Souto-Carneiro MM, Fonseca JE. (2010)
Neutrophils in rheumatoid arthritis: More than simple final
effectors. Autoimmun Rev 2010 9, 531-535.
Cascão,
R., Rosário, H.S., Fonseca, J.E. (2009) Neutrophils:
warriors and commanders in immune mediated inflammatory diseases.
Acta Reumatol Port 34 (2B), 313-326.
Lopes
de Almeida, J.P., Carvalho, F.A., Silva-Herdade, A.S.,
Santos-Freitas, T., Saldanha, C. (2009) Redox
thiol status plays a central
role in the mobilization and metabolism of nitric oxide in human red
blood cells. Cell
Biol Int 33 (3), 268-275.
Sequeira,
A., Artoli, A.M., Silva-Herdade, A.S. Saldanha, C. (2009) Leukocytes
dynamics in microcirculation under shear-thining blood flow.
Computers
& Mathematics with Applications 58 (5), 1035-1044.
de Almeida, J.P., Freitas-Santos, T., Saldanha,
C. (2009) Fribrinogen-dependent signaling im microvascular erytrocyte
finction: implications on nitric oxide efflux. J Membr Biol
Carvalho,
F.A., de Almeida, J.P., Freitas-Santos, T., Saldanha, C.
(2009)Modulation
of erythrocyte acetylcholinesterase activity and its association with
G protein-band 3 interactions. J Membr Biol 228(2), 89-97.
Artoli
AM, Sequeira A, Silva-Herdade AS, Saldanha C (2008)Localized
hydrodynamics of clustering leukocytes. Clin Hemorheol Microcirc 39
(1-4), 375-380.
Carvalho
FA, Almeida JP, Fernandes IO, Freitas-Santos T, Saldanha C. (2008)
Non-neuronal cholinergic system and signal transduction pathways
mediated by band 3 in red blood cells. Clin Hemorheol Microcirc
40:207-227.
de
Oliveira S, Silva-Herdade AS, Saldanha C. (2008) Modulation of
erythrocyte deformability by PKC activity. Clin Hemorheol Microcirc
39 (1-4), 363-373.
Almeida
JP, Carvalho FA, Freitas T, Saldanha C. (2008) Modulation of
hemorheological parameters by the erythrocyte redox thiol status.
Clin Hemorheol Microcirc 40, 99-111.
Vieira
CR, Castanho M, Saldanha C, Santos NC. (2008)
Enfuvirtide effects on human erythrocytes and lymphocytes functional
properties. J Pept Sci 14, 448-454.
Canhão
H, Fonseca JE, Caetano-Lopes J, Saldanha C, Queiroz MV. (2008)
Assessment of laboratory measurements and -308 TNFalpha gene promoter
polymorphisms in normal bone mineral density. Clin Rheumatol 27,
301-307.
Full publications list
2012
J.
Galindo-Villegas, D. García-Moreno, S. de Oliveira, J. Meseguer, V.
Mulero, (2012) Regulation of immunity and
disease resistance by commensal microbes and chromatin modifications
during zebrafish development.” Proc Natl Acad Sci U S A., Sep 25,
109(39), 2605-2614
de
Almeida VV, Calado A, Rosário HS, Saldanha C. (2012) Differential
effect of soluble fibrinogen as a neutrophil activator. Microvasc
Res. 83(3):332-6.
C.
Saldanha, (2012) Fibrinogen interaction
with the red blood cell membrane. Clin Hemorheol Microcirc., Sep 7.
[Epub ahead of print]
Lopes
de Almeida JP, Oliveira S, Saldanha C. (2012) Erythrocyte
as a biological sensor. Clin Hemorheol Microcirc. 51(1), 1 -20.
C.
Saldanha, T. Freitas, JP. Almeida, (2012)
Fibrinogen effects on erythrocyte nitric oxide mobilization in
presence of acetylcholine. Life Sci., Jul 11. [Epub ahead of print]
de
Oliveira, P Gomes, AQ, Pacheco, TR,
Vitorino de Almeida, V, Saldanha, C, Calado, A (2012) Cell-specific
regulation of acetylcholinesterase expression under inflammatory
conditions. Clin Hemorheol Microcirc. 51(2), 129-37.
JP
Lopes de Almeida, T Freitas-Santos, C Saldanha, (2012) Erythrocyte
deformability dependence on band 3 protein in an in-vitro model of
hyperfibrinogenemia. Clin Hemorheol Microcirc, 50(3), 213-9.
2011
Lopes
de Almeida, JP, Freitas-Santos, T, Saldanha, C. (2011) Evidence that
the degree of band 3 phosphorylation modulates human erythrocytes
nitric oxide efflux - in vitro model of hyperfibrinogenemia. Clinical
Hemorheology and Microcirculation 49 (1), 407-16.
Saldanha,
C, Lopes de Almeida, JP. (2011) Erythrocyte
as a link between basic and clinical research. Clinical
Hemorheology and Microcirculation 49 (1), 463-72.
Moura,
RA, Cascao, R, Perpetuo, I, Canhao, H, Vieira-Sousa, E, Mourao, AF,
Rodrigues, AM, Polido-Pereira, J, Queiroz, MV, Rosario, HS,
Souto-Carneiro, MM, Graca, L, Fonseca, JE. (2011)
Cytokine pattern in very early rheumatoid arthritis favours B-cell
activation and survival. Rheumatology
50 (2), 278-282
de
Oliveira, S, de Almeida, VV, Calado, A, Rosário, HS, Saldanha, C.
(2011) Integrin-associated protein (CD47) is a putative mediator for
soluble fibrinogen interaction with human red blood cells membrane.
Biochim Biophys Acta
1818 (3), 481-490
Santos,
MJ, Pedro, LM, Canhão, H, Fernandes e Fernandes, J, Canas da Silva,
J, Fonseca, JE, Saldanha C. (2011) Hemorheological parameters are
related to subclinical atherosclerosis in systemic lupus
erythematosus and rheumatoid arthritis patients. Atherosclerosis
219(2), 821-6.
Silva-Herdade,
AS, Saldanha, C. (2011) Hemorheological effects of valsartan in
L-NAME induced hypertension in rats. The
Open Circ Vasc J 4, 1-5.
Lopes
de Almeida JP, Freitas-Santos, T, Saldanha C. (2011) Erythrocyte
deformability dependence on Band 3 protein in an in vitro model of
hyperfibrinogenemia. Clin Hemorh Microc 44, 1-6.
Lopes
de Almeida, JP, de Oliveira, S, Saldanha, C. (2011) Erythrocyte as a
Biological Sensor. Clin Hemorh Microc 48, 1-20.
2010
Saldanha,
C, Lopes de Almeida, JP, Freitas, T, Oliveira, S, Silva-Herdade, AS.
(2010) Erythrocyte deformability responses to
shear stress under external and internal stimuli influences. Series
on Biomechanics 25, 54-60.
Lopes
de Almeida J.P., Saldanha, C. (2010) Dithiothreitol
revisited in red cells: a new head for an old hat. Clin
Hemorheol Microcirc.
46, 51-56.
Martin
Martins, J., Vale, S., Ferreira, F., Fagundes, M.J., Carmo, I.,
Saldanha, C., Martins e Silva, J. (2010) Plasma
corticotropin releasing hormone during the feeling of induced
emotions. Neuro
Endocrinol Lett.
31, 250-5.
de
Almeida, J.P., Saldanha, C. (2010) Nonneuronal
cholinergic system in human erythrocytes: biological role and
clinical relevance. J
Membr Biol.
234(3), 227-34.
Santos,
N.C., Silva, J.M., Freitas, T., Doroana, M., Duarte, N., Tavares, L.,
Antunes, F., Saldanha, C. (2010) Blood
cell membrane fluidity and intracellular Ca2+ changes in
antiretroviral-naïve and -treated HIV-1-infected patients. The
Scientific World Journal.
10, 350-5.
de
Oliveira, S., Saldanha, C. (2010) An
overview about erythrocyte membrane. Clin
Hemorheol Microcirc.
44, 63-74.
Moura
RA, Cascão R, Perpétuo I, Canhão H, Vieira-Sousa E, Mourão AF,
Rodrigues AM, Polido-Pereira J, Queiroz MV, Rosário HS,
Souto-Carneiro MM, Graca L, Fonseca JE (2010) Cytokine pattern in
very early rheumatoid arthritis favours B-cell activation and
survival. Rheumatology,
50(2),
278-282.
Cascão
R, Moura RA, Perpétuo I, Canhão H, Vieira-Sousa E, Mourão AF,
Rodrigues AM, Polido-Pereira J, Queiroz MV, Rosário HS,
Souto-Carneiro MM, Graca L, Fonseca JE (2010) Identification of a
cytokine network sustaining neutrophil and Th17 activation in
untreated early rheumatoid arthritis. Arthritis
Res Ther
12, R196.
Cascão
R, Rosário HS, Souto-Carneiro MM, Fonseca JE. Neutrophils
in rheumatoid arthritis: More than simple final effectors (2010)
Autoimmun Rev
2010 9, 531-535.
2009
Cascão,
R., Rosário, H.S., Fonseca, J.E. (2009) Neutrophils: warriors and
commanders in immune mediated inflammatory diseases. Acta
Reumatol Port 34 (2B), 313-326.
Lopes
de Almeida, J.P., Carvalho, F.A., Silva-Herdade, A.S.,
Santos-Freitas, T., Saldanha, C. (2009) Redox thiol status plays a
central role in the mobilization and metabolism of nitric oxide in
human red blood cells. Cell
Biol Int
33 (3), 268-275.
Sequeira,
A., Artoli, A.M., Silva-Herdade, A.S. Saldanha, C. (2009) Leukocytes
dynamics in microcirculation under shear-thining blood flow.
Computers & Mathematics with Applications
58 (5), 1035-1044.
de
Almeida, J.P., Freitas-Santos, T., Saldanha, C. (2009)
Fribrinogen-dependent signaling im microvascular erytrocyte finction:
implications on nitric oxide efflux. J
Membr Biol 231(1), 47-53
Carvalho,
F.A., de Almeida, J.P., Freitas-Santos, T., Saldanha, C. (2009)
Modulation of erythrocyte acetylcholinesterase activity and its
association with G protein-band 3 interactions. J
Membr Biol 228(2), 89-97.
2008
Artoli
AM, Sequeira A, Silva-Herdade AS, Saldanha C (2008) Localized
hydrodynamics of clustering leukocytes. Clin
Hemorheol Microcirc 39 (1-4), 375-380.
Carvalho
FA, Almeida JP, Fernandes IO, Freitas-Santos T, Saldanha C. (2008)
Non-neuronal cholinergic system and signal transduction pathways
mediated by band 3 in red blood cells. Clin
Hemorheol Microcirc 40:207-227.
de
Oliveira S, Silva-Herdade AS, Saldanha C. (2008) Modulation of
erythrocyte deformability by PKC activity. Clin
Hemorheol Microcirc 39 (1-4), 363-373.
Almeida
JP, Carvalho FA, Freitas T, Saldanha C. (2008) Modulation of
hemorheological parameters by the erythrocyte redox thiol status.
Clin Hemorheol Microcirc 40, 99-111.
Vieira
CR, Castanho M, Saldanha C, Santos NC. (2008)
Enfuvirtide effects on human erythrocytes and lymphocytes functional
properties. J Pept Sci 14, 448-454.
Canhão
H, Fonseca JE, Caetano-Lopes J, Saldanha C, Queiroz MV. (2008)
Assessment of laboratory measurements and -308 TNFalpha gene promoter
polymorphisms in normal bone mineral density. Clin
Rheumatol 27, 301-307.
2007
Artoli,
A.M., Sequeira, A., Silva-Herdade, A.S., Saldanha, C. (2007)
Leukocytes rolling and recruitment by endothelial cells:
hemorheological experiments and numerical simulations. J
Biomech. 40(15):
3493-502.
Gonçalves,
S., Vasco Maria, A., Silva-Herdade, A.S., Martins e Silva, J.,
Saldanha, C. (2007) Milk enriched with phytosterols reduces plasma
cholesterol levels in healthy and hypercholesterolemic subjects.
Nutrition Research 27; 200-205.
Silva,
A.S., Saldanha C., Martins e Silva, J. (2007) Effects of velnacrine
maleate in the leukocyte-endothelial cell interactions in rat
cremaster microcirculatory effects. Clin.
Hemorheol. Microcirc. 36: 235-246.
Santos,
S.C., Miguel, C., Domingues, I., Calado, A., Zhu, Z., Wu, Y. and
Dias, S. (2007) VEGF and VEGFR-2 (KDR) internalization is required
for endothelial recovery during wound healing. Exp. Cell
Res. 313,1561-1574.
Santos,
S.C.R., Vala, I., Miguel, C., Barata, J.P., Garção, P., Agostinho,
P., Mendes, M., Coelho, A.V., Calado, A., Oliveira, C.R., Martins e
Silva, J. and Saldanha, C. (2007) Expression and subcellular
localization of a novel nuclear acetylcholinesterase protein. J.
Biol. Chem. 282, 25597-25603.
Saldanha,
C., Silva, A.S., Gonçalves, S., Martins e Silva, J. (2007)
Modulation of erythrocyte hemorheological properties by band 3
phosphorylation and dephosphorylation. Clin
Hemorheol and Microcirc. 36; 183-194.
Gonçalves,
S., Santos, N.C., Martins-Silva, J., Saldanha, C. (2007) Fluorescence
spectroscopy evaluation of fibrinogen-β-estradiol binding. J.
Photochem. Photobiol. B-Biol. 86:
170-176.
Almeida,
J.P. (2007) Circulating Acetylcholine Revisited: Physiological and
Clinical Relevance. JEMSA – Journal of
EMSA on Medical and Scientific Affairs
2007, 26-32.
2006-…
Gonçalves S, Santos NC, Martins-Silva J, Saldanha
C. (2006) Fluorescence
spectroscopy evaluation of fibrinogen-beta-estradiol binding. J
Photochem Photobiol B. 86(2), 170-6.
Martins-Silva J, Santos NC, Doroana M, Duarte N,
Tavares L, Antunes F, Saldanha C. (2006) Changes
in blood cell membrane properties in HIV type-1-infected patients.
AIDS Res Hum Retroviruses.
22(9), 849-53.
Carvalho FA, Maria AV, Braz Nogueira JM, Guerra J,
Martins-Silva J, Saldanha C. (2006) The
relation between the erythrocyte nitric oxide and hemorheological
parameters. Clin Hemorheol
Microcirc. 35(1-2), 341-7.
Gonçalves S, Maria AV, Silva AS, Martins-Silva J,
Saldanha C. (2006) Phytosterols
in milk as a depressor of plasma cholesterol levels: experimental
evidence with hypercholesterolemic Portuguese subjects. Clin
Hemorheol Microcirc. 35(1-2), 251-5.
Silva AS, Saldanha C, Martins-Silva J. (2006)
Effects of
low-fat milk enriched with phytosterols on plasma cholesterol
concentrations and hemorheological parameters of Wistar rats.
Clin Hemorheol Microcirc.
35(1-2), 245-50.
Gonçalves S, Santos NC, Martins-Silva J, Saldanha
C. (2006) Fibrinogen-beta-estradiol
binding studied by fluorescence spectroscopy: denaturation and pH
effects. J Fluoresc.
16(2), 207-13.
Carvalho FA, Graça LM, Martins-Silva J, Saldanha
C. (2005) Biochemical
characterization of human umbilical vein endothelial cell membrane
bound acetylcholinesterase. FEBS J.
272(21), 5584-94.
Santos NC, Martins-Silva J, Saldanha C. (2005)
Gramicidin D
and dithiothreitol effects on erythrocyte exovesiculation. Cell
Biochem Biophys. 43(3), 419-30.
Sargento
L, Saldanha C, Monteiro J, Perdigão C, e Silva JM. (2005)
Long-term
prognostic value of protein C activity, erythrocyte aggregation and
membrane fluidity in transmural myocardial infarction. Thromb
Haemost.
94(2), 380-8.
Santos
NC, Martins-Silva J, Saldanha C. (2005) PTEN
"meets" DMSO. Leuk
Res.
29(4), 361-2.
Lund,
E., Guttinger, S., Calado, A., Dahlberg, J.E., Kutay, U. (2004)
Nuclear export of microRNA precursors. Science
303: 95-98.
Rosário
HS, Waldo SW, Becker SA, Schmid-Schönbein GW. (2004) Pancreatic
trypsin increases matrix metalloproteinase-9 accumulation and
activation during acute intestinal ischemia-reperfusion in the rat.
Am J Pathol.
164: 1707-16.
Carvalho,
F.A., Martins-Silva, J., Saldanha, C. (2004) Amperometric
measurements of nitric oxide in erythrocytes. Biosensors
and Bioelectronics 20 (3): 505-508.
Carvalho
FA, Mesquita R, Martins-Silva J, Saldanha C. (2004) Acetylcholine
and choline effects on erythrocyte nitrite and nitrate levels. J
Appl Toxicol. 24(6), 419-27.
Fitzal
F, Delano FA, Young C, Rosario HS, Junger WG, Schmid-Schönbein GW.
(2003) Pancreatic enzymes sustain systemic inflammation after an
initial endotoxin challenge. Surgery
134: 446-56.
Waldo
SW, Rosario HS, Penn AH, Schmid-Schönbein GW. (2003) Pancreatic
digestive enzymes are potent generators of mediators for leukocyte
activation and mortality. Shock 20: 138-43.
Santos,
N.C., Figueira-Coelho, J., Martins-Silva, J., Saldanha, C. (2003)
Multidisciplinary utilization of dimethyl sulfoxide: pharmacological,
cellular, and molecular aspect. Biochem.
Pharmacol. 65: 1035-1041.
Santos,
N.C., Silva, A.C., Castanho, M.A.R.B., Martins-Silva, J., Saldanha,
C. (2003) Evaluation of lipopolysaccharide aggregation by light
scattering spectroscopy. ChemBioChem
4: 96-100.
Fitzal
F, DeLano FA, Young C, Rosario HS, Schmid-Schönbein GW. (2003)
Pancreatic protease inhibition during shock attenuates cell
activation and peripheral inflammation. J.
Vasc. Res. 39: 320-9.
Calado,
A., Treichel, N., Muller, E.C., Otto, A., Kutay, U. (2002)
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A
and tRNA. EMBO J.
21: 6216-6224.
Santos,
N.C., Figueira-Coelho, J., Saldanha, C. et al (2002) Biochemical,
biophysical and haemorheological effects of dimethylsulphoxide on
human erythrocyte calcium loading. Cell
Calcium 31 (4): 183-188.
